منابع مشابه
COX-2-dependent cardiac failure in Gh/tTG transgenic mice.
Gh is a GTP binding protein that couples to the thromboxane receptor (TP), but also functions as tissue transglutaminase II (tTG). A transgenic mouse model was generated in which Gh was overexpressed (GhOE) in ventricular myocytes under the control of the alpha-myosin heavy chain promoter. Heart rate was elevated and both blood pressure and left ventricular ejection fraction were depressed in G...
متن کاملGH dependence and GH withdrawal syndrome in GH treatment of short normal children: evidence from growth and cardiac output.
The child's age is a significant determinant of the outcome of GH therapy; prepubertal children respond better on both short term and long term growth, whereas adolescents tend to accelerate their bone maturation more than growth. The present study was designed to evaluate the efficacy of an interrupted GH therapy protocol of young, short normal children. GH was given for a period of 3 years, o...
متن کاملThe GH/IGF-1 Axis and Heart Failure
The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis regulates cardiac growth, stimulates myocardial contractility and influences the vascular system. The GH/IGF-1 axis controls intrinsic cardiac contractility by enhancing the intracellular calcium availability and regulating expression of contractile proteins; stimulates cardiac growth, by increasing protein synthesis; modifies sy...
متن کاملHuge Intracavitary Cardiac Hyadatid Cyst Presenting with Heart Failure
Although cardiac involvement is an infrequent presentation in human hydatidosis, early diagnosis and prompt surgical intervention of cardiac hydatid cyst are of utmost importance for the prevention of potential complications. We report a young female patient who presented with a huge cardiac hydatid cyst and severe heart failure symptoms undergoing successful surgical cyst removal with late fol...
متن کاملVein of Galen Aneurysmal Malformation and High-output Cardiac Failure in a Newborn
Background: Vein of Galen aneurysm (VGA) is the most common form of symptomatic cerebrovascular malformation in neonates. It develops in a fetus in the first trimester of pregnancy due to unknown reasons, but it is likely to have a genetic etiology. The prognosis of VGA is usually poor, particularly in newborns with heart failure due to high-flow intracerebral shunt. Surgery and endovascular em...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 2001
ISSN: 0021-972X
DOI: 10.1210/jc.86.10.4635